If you are currently dating someone with bipolar disorder , you may struggle with a number of challenges like how you can support him or her while still caring for yourself. Knowledge is power, so learn as much as you can about your partner's disease. This will also be a healthy sign to him or her that you care. That being said, bipolar disorder is a complex disease. Try not to get too bogged down in the details. For more mental health resources, see our National Helpline Database. It is important when you are dating someone with bipolar disorder to recognize that their disease is a piece of their life pie, and not their whole identity.
However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at Seroquel side effects in more detail. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Skip to Content. A prospective, longitudinal study followed pregnant women with a history of major depressive disorder who were euthymic and taking antidepressants at the beginning of pregnancy. The women who discontinued antidepressants during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressants.
Consider the risk of untreated depression when discontinuing or changing treatment with antidepressant medication during pregnancy and postpartum.
These symptoms varied in severity. Some neonates recovered within hours or days without specific treatment; others required prolonged hospitalization. Published data from observational studies, birth registries, and case reports on the use of atypical antipsychotics during pregnancy do not report a clear association with antipsychotics and major birth defects.
A retrospective cohort study from a Medicaid database of women exposed to antipsychotics during pregnancy did not indicate an overall increased risk of major birth defects. When pregnant rats and rabbits were exposed to quetiapine during organogenesis, there was no teratogenic effect in fetuses. There are no consistent adverse events that have been reported in infants exposed to quetiapine through breast milk.
There is no information on the effects of quetiapine on milk production. Based on the pharmacologic action of quetiapine D2 antagonismtreatment with Seroquel may result in an increase in serum prolactin levels, which may lead to a reversible reduction in fertility in females of reproductive potential [see Warnings and Precautions 5.
In general, the adverse reactions observed in children and adolescents during the clinical trials were similar to those in the adult population with few exceptions.
Increases in systolic and diastolic blood pressure occurred in children and adolescents and did not occur in adults. The efficacy and safety of Seroquel in the treatment of schizophrenia in adolescents aged years were demonstrated in one 6-week, double-blind, placebo-controlled trial [see Indications and Usage 1. Safety and effectiveness of Seroquel in pediatric patients less than 13 years of age with schizophrenia have not been established.
The safety and effectiveness of Seroquel in the maintenance treatment of bipolar disorder has not been established in pediatric patients less than 18 years of age. The safety and effectiveness of Seroquel in the maintenance treatment of schizophrenia has not been established in any patient population, including pediatric patients.
The efficacy and safety of Seroquel in the treatment of mania in children and adolescents ages years with bipolar I disorder was demonstrated in a 3-week, double-blind, placebo controlled, multicenter trial [see Indications and Usage 1. Safety and effectiveness of Seroquel in pediatric patients less than 10 years of age with bipolar mania have not been established. Safety and effectiveness of Seroquel in pediatric patients less than 18 years of age with bipolar depression have not been established.
A clinical trial with Seroquel XR was conducted in children and adolescents years of age with bipolar depression, efficacy was not established. In general, there was no indication of any different tolerability of Seroquel in the elderly compared to younger adults. Nevertheless, the presence of factors that might decrease pharmacokinetic clearance, increase the pharmacodynamic response to Seroquel, or cause poorer tolerance or orthostasis, should lead to consideration of a lower starting dose, slower titration, and careful monitoring during the initial dosing period in the elderly.
It is important when you are dating someone with bipolar disorder to recognize that their disease is a piece of their life pie, and not their whole identity. ? ? That being said, to a large degree, a person's bipolar disorder contributes significantly to their behavior, personality, and relationships. For the most up-to-date information on the management of Seroquel overdosage, contact a certified Regional Poison Control Center . Seroquel Description Seroquel (quetiapine) is an atypical antipsychotic belonging to a chemical class, the dibenzothiazepine derivatives. All people who take Seroquel (quetiapine tablets) need to be watched closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
Clinical experience with Seroquel in patients with renal impairment is limited [see Clinical Pharmacology Since quetiapine is extensively metabolized by the liver, higher plasma levels are expected in patients with hepatic impairment. Seroquel has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence. Consequently, patients should be evaluated carefully for a history of drug abuse, and such patients should be observed closely for signs of misuse or abuse of Seroquel, e.
In clinical trials, survival has been reported in acute overdoses of up to 30 grams of quetiapine. Most patients who overdosed experienced no adverse reactions or recovered fully from the reported reactions.
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Death has been reported in a clinical trial following an overdose of Patients with pre-existing severe cardiovascular disease may be at an increased risk of the effects of overdose [see Warnings and Precautions 5. One case, involving an estimated overdose of mg, was associated with hypokalemia and first-degree heart block. In post-marketing experience, there were cases reported of QT prolongation with overdose. Establish and maintain an airway and ensure adequate oxygenation and ventilation.
Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. Appropriate supportive measures are the mainstay of management.
For the most up-to-date information on the management of Seroquel overdosage, contact a certified Regional Poison Control Center The chemical designation is 2-[2- 4-dibenzo [ b,f ] [1,4]thiazepinylpiperazinyl ethoxy]-ethanol fumarate salt. It is present in tablets as the fumarate salt. All doses and tablet strengths are expressed as milligrams of base, not as fumarate salt. The structural formula is:.
Quetiapine fumarate is a white to off-white crystalline powder which is moderately soluble in water.
Seroquel is supplied for oral administration as 25 mg round, peach50 mg round, whitemg round, yellowmg round, whitemg capsule-shaped, whiteand mg capsule-shaped, yellow tablets. Inactive ingredients are povidone, dibasic dicalcium phosphate dihydrate, microcrystalline cellulose, sodium starch glycolate, lactose monohydrate, magnesium stearate, hypromellose, polyethylene glycol, and titanium dioxide.
The 25 mg tablets contain red ferric oxide and yellow ferric oxide and the mg and mg tablets contain only yellow ferric oxide. Each 25 mg tablet contains Each 50 mg tablet contains Each mg tablet contains The mechanism of action of quetiapine in the listed indications is unclear. However, the efficacy of quetiapine in these indications could be mediated through a combination of dopamine type 2 D 2 and serotonin type 2 5HT 2 antagonism.
The active metabolite, N-desalkyl quetiapine norquetiapinehas similar activity at D2, but greater activity at 5HT 2A receptors, than the parent drug quetiapine. Quetiapine and its metabolite, norquetiapine, have affinity for multiple neurotransmitter receptors with norquetiapine binding with higher affinity than quetiapine in general. Quetiapine activity is primarily due to the parent drug.
The multiple-dose pharmacokinetics of quetiapine are dose-proportional within the proposed clinical dose range, and quetiapine accumulation is predictable upon multiple dosing. Elimination of quetiapine is mainly via hepatic metabolism with a mean terminal half-life of about 6 hours within the proposed clinical dose range. Steady-state concentrations are expected to be achieved within two days of dosing. Quetiapine is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P enzymes.
At steady state the pharmacokinetics of the parent compound, in children and adolescents years of agewere similar to adults. When adjusted for dose and weight, the pharmacokinetics of the metabolite, norquetiapine, was similar between children and adolescents and adults [see Use in Specific Populations 8. Quetiapine is rapidly absorbed after oral administration, reaching peak plasma concentrations in 1.
In vitroquetiapine did not affect the binding of warfarin or diazepam to human serum albumin. In turn, neither warfarin nor diazepam altered the binding of quetiapine. Quetiapine is extensively metabolized by the liver. The major metabolic pathways are sulfoxidation to the sulfoxide metabolite and oxidation to the parent acid metabolite; both metabolites are pharmacologically inactive. In vitro studies using human liver microsomes revealed that the cytochrome P 3A4 isoenzyme is involved in the metabolism of quetiapine to its major, but inactive, sulfoxide metabolite and in the metabolism of its active metabolite N-desalkyl quetiapine.
Dosage adjustment is therefore not needed in these patients [see Use in Specific Populations 8. In two of the 8 hepatically impaired patients, AUC and C max were 3 times higher than those observed typically in healthy subjects. Since quetiapine is extensively metabolized by the liver, higher plasma levels are expected in the hepatically impaired population, and dosage adjustment may be needed [see Dosage and Administration 2.
The in vivo assessments of effect of other drugs on the pharmacokinetics of quetiapine are summarized in Table 17 [see Dosage and Administration 2. In vitro enzyme inhibition data suggest that quetiapine and 9 of its metabolites would have little inhibitory effect on in vivo metabolism mediated by cytochromes CYP 1A2, 2C9, 2C19, 2D6, and 3A4.
Carcinogenicity studies were conducted in C57BL mice and Wistar rats. These doses are equivalent to 0. There were statistically significant increases in thyroid gland follicular adenomas in male mice at doses 1.
Mammary gland adenocarcinomas were statistically significantly increased in female rats at all doses tested 0. Thyroid follicular cell adenomas may have resulted from chronic stimulation of the thyroid gland by thyroid stimulating hormone TSH resulting from enhanced metabolism and clearance of thyroxine by rodent liver.
Changes in TSH, thyroxine, and thyroxine clearance consistent with this mechanism were observed in subchronic toxicity studies in rat and mouse and in a 1-year toxicity study in rat; however, the results of these studies were not definitive.
The relevance of the increases in thyroid follicular cell adenomas to human risk, through whatever mechanism, is unknown. Antipsychotic drugs have been shown to chronically elevate prolactin levels in rodents. Serum measurements in a 1-year toxicity study showed that quetiapine increased median serum prolactin levels a maximum of and fold in male and female rats, respectively.
Increases in mammary neoplasms have been found in rodents after chronic administration of other antipsychotic drugs and are considered to be prolactin-mediated. The relevance of this increased incidence of prolactin-mediated mammary gland tumors in rats to human risk is unknown [see Warnings and Precautions 5. Quetiapine was not mutagenic or clastogenic in standard genotoxicity tests.
The mutagenic potential of quetiapine was tested in the in vitro Ames bacterial gene mutation assay and in the in vitro mammalian gene mutation assay in Chinese Hamster Ovary cells. Drug-related effects included increases in interval to mate and in the number of matings required for successful impregnation. These effects continued to be observed at 3 times the MRHD even after a two-week period without treatment.
Drug-related effects included decreases in matings and in matings resulting in pregnancy, and an increase in the interval to mate. Quetiapine caused a dose-related increase in pigment deposition in thyroid gland in rat toxicity studies which were 4 weeks in duration or longer and in a mouse 2-year carcinogenicity study.
Pigment deposition was shown to be irreversible in rats. The identity of the pigment could not be determined, but was found to be co-localized with quetiapine in thyroid gland follicular epithelial cells. The functional effects and the relevance of this finding to human risk are unknown. This finding may be due to inhibition of cholesterol biosynthesis by quetiapine.
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Quetiapine caused a dose-related reduction in plasma cholesterol levels in repeat-dose dog and monkey studies; however, there was no correlation between plasma cholesterol and the presence of cataracts in individual dogs. The appearance of deltacholestanol in plasma is consistent with inhibition of a late stage in cholesterol biosynthesis in these species. The efficacy of Seroquel in the treatment of schizophrenia was established in 3 short-term 6-week controlled trials of inpatients with schizophrenia who met DSM III-R criteria for schizophrenia.
Although a single fixed dose haloperidol arm was included as a comparative treatment in one of the three trials, this single haloperidol dose group was inadequate to provide a reliable and valid comparison of Seroquel and haloperidol. Several instruments were used for assessing psychiatric signs and symptoms in these studies, among them the Brief Psychiatric Rating Scale BPRSa multi-item inventory of general psychopathology traditionally used to evaluate the effects of drug treatment in schizophrenia.
The BPRS psychosis cluster conceptual disorganization, hallucinatory behavior, suspiciousness, and unusual thought content is considered a particularly useful subset for assessing actively psychotic schizophrenic patients. A second traditional assessment, the Clinical Global Impression CGIreflects the impression of a skilled observer, fully familiar with the manifestations of schizophrenia, about the overall clinical state of the patient.
The primary efficacy results of these three studies in the treatment of schizophrenia in adults is presented in Table Examination of population subsets race, gender, and age did not reveal any differential responsiveness on the basis of race or gender, with an apparently greater effect in patients under the age of 40 years compared to those older than The clinical significance of this finding is unknown.
The efficacy of Seroquel in the treatment of schizophrenia in adolescents years of age was demonstrated in a 6-week, double-blind, placebo-controlled trial study 4. The primary efficacy results of this study in the treatment of schizophrenia in adolescents is presented in Table The efficacy of Seroquel in the acute treatment of manic episodes was established in 3 placebo-controlled trials in patients who met DSM-IV criteria for bipolar I disorder with manic episodes.
These trials included patients with or without psychotic features and excluded patients with rapid cycling and mixed episodes. Of these trials, 2 were monotherapy 12 weeks and 1 was adjunct therapy 3 weeks to either lithium or divalproex. Key outcomes in these trials were change from baseline in the Young Mania Rating Scale YMRS score at 3 and 12 weeks for monotherapy and at 3 weeks for adjunct therapy.
Adjunct therapy is defined as the simultaneous initiation or subsequent administration of Seroquel with lithium or divalproex.
The efficacy of Seroquel in the acute treatment of bipolar mania was established in 2 placebo-controlled trials. Patients may or may not have received an adequate treatment course of lithium or divalproex prior to randomization. Seroquel was superior to placebo when added to lithium or divalproex alone in the reduction of YMRS total score study 3 in Table The primary efficacy results of these studies in the treatment of mania in adults is presented in Table The efficacy of Seroquel in the acute treatment of manic episodes associated with bipolar I disorder in children and adolescents years of age was demonstrated in a 3-week, double-blind, placebo-controlled, multicenter trial study 4 in Table The primary efficacy variable was the mean change from baseline in total YMRS score.
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These studies included patients with either bipolar I or II disorder and those with or without a rapid cycling course. Patients randomized to Seroquel were administered fixed doses of either mg or mg once daily. The primary rating instrument used to assess depressive symptoms in these studies was the Montgomery-Asberg Depression Rating Scale MADRSa item clinician-rated scale with scores ranging from 0 to Improvement in symptoms, as measured by change in MADRS score relative to placebo, was seen in both studies at Day 8 week 1 and onwards.
In these studies, no additional benefit was seen with the mg dose. For the mg dose group, statistically significant improvements over placebo were seen in overall quality of life and satisfaction related to various areas of functioning, as measured using the Q-LES-Q SF.
The primary efficacy results of these studies in the acute treatment of depressive episodes associated with bipolar disorder in adults is presented in Table The trials included patients whose most recent episode was manic, depressed, or mixed, with or without psychotic features. In the open-label phase, patients were required to be stable on Seroquel plus lithium or divalproex for at least 12 weeks in order to be randomized.
On average, patients were stabilized for 15 weeks. The primary endpoint in these studies was time to recurrence of a mood event manic, mixed, or depressed episode. In both studies, Seroquel was superior to placebo in increasing the time to recurrence of any mood event. The treatment effect was present for increasing time to recurrence of both manic and depressed episodes.
The effect of Seroquel was independent of any specific subgroup assigned mood stabilizer, sex, age, race, most recent bipolar episode, or rapid cycling course. Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking Seroquel. Patients and caregivers should be advised that elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at increased risk of death compared with placebo.
Quetiapine is not approved for elderly patients with dementia-related psychosis [see Warnings and Precautions 5. Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotor restlessnesshypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down.
Families and caregivers of patients should be advised to look for the emergence of such symptoms on a day-to-day basis, since changes may be abrupt. Such symptoms should be reported to the patient's prescriber or health professional, especially if they are severe, abrupt in onset, or were not part of the patient's presenting symptoms.
Symptoms such as these may be associated with an increased risk for suicidal thinking and behavior and indicate a need for very close monitoring and possibly changes in the medication [see Warnings and Precautions 5.
Patients should be advised to report to their physician any signs or symptoms that may be related to NMS. These may include muscle stiffness and high fever [see Warnings and Precautions 5.
Patients should be aware of the symptoms of hyperglycemia high blood sugar and diabetes mellitus. Patients who are diagnosed with diabetes, those with risk factors for diabetes, or those that develop these symptoms during treatment should have their blood glucose monitored at the beginning of and periodically during treatment [see Warnings and Precautions 5.
Patients should be advised that elevations in total cholesterol, LDL-cholesterol and triglycerides and decreases in HDL-cholesterol may occur. Patients should have their lipid profile monitored at the beginning of and periodically during treatment [see Warnings and Precautions 5.
Patients should be advised that they may experience weight gain. Patients should have their weight monitored regularly [see Warnings and Precautions 5. Patients should be advised of the risk of orthostatic hypotension symptoms include feeling dizzy or lightheaded upon standing, which may lead to fallsespecially during the period of initial dose titration, and also at times of re-initiating treatment or increases in dose [see Warnings and Precautions 5.
Children and adolescent patients should have their blood pressure measured at the beginning of, and periodically during, treatment [see Warnings and Precautions 5. Patients should be advised of the risk of somnolence or sedation which may lead to fallsespecially during the period of initial dose titration.
Patients should be cautioned about performing any activity requiring mental alertness, such as operating a motor vehicle including automobiles or operating machinery, until they are reasonably certain quetiapine therapy does not affect them adversely [see Warnings and Precautions 5.
Patients should be advised regarding appropriate care in avoiding overheating and dehydration [see Warnings and Precautions 5.
As with other medications, patients should be advised to notify their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs [see Drug Interactions 7. Advise pregnant women to notify their healthcare provider if they become pregnant or intend to become pregnant during treatment with Seroquel. Advise patients that there is a pregnancy registry that monitors pregnancy outcomes in women exposed to Seroquel during pregnancy [see Use in Specific Populations 8.
Advise females of reproductive potential that Seroquel may impair fertility due to an increase in serum prolactin levels. The effects on fertility are reversible [see Use in Specific Populations 8.
Seroquel is indicated as an integral part of a total treatment program for adolescents with schizophrenia and pediatric bipolar disorder that may include other measures psychological, educational, and social. Effectiveness and safety of Seroquel have not been established in pediatric patients less than 13 years of age for schizophrenia or less than 10 years of age for bipolar mania.
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Appropriate educational placement is essential and psychosocial intervention is often helpful. Read this Medication Guide before you start taking Seroquel and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:.
Before you take Seroquel, tell your healthcare provider if you have or have had:. Tell the healthcare provider about all the medicines that you take or recently have taken including prescription medicines, over-the-counter medicines, herbal supplements, and vitamins.
Seroquel and other medicines may affect each other causing serious side effects. Seroquel may affect the way other medicines work, and other medicines may affect how Seroquel works. Tell your healthcare provider if you are having a urine drug screen because Seroquel may affect your test results.
Tell those giving the test that you are taking Seroquel. These are not all the possible side effects of Seroquel. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide.
Do not use Seroquel for a condition for which it was not prescribed.
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Do not give Seroquel to other people, even if they have the same symptoms you have. It may harm them. This Medication Guide summarizes the most important information about Seroquel.
If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Seroquel that is written for health professionals.
Inactive ingredients: povidone, dibasic dicalcium phosphate dihydrate, microcrystalline cellulose, sodium starch glycolate, lactose monohydrate, magnesium stearate, hypromellose, polyethylene glycol, and titanium dioxide. The 25 mg tablets contain red and yellow ferric oxide. The mg and mg tablets contain only yellow ferric oxide. This Medication Guide has been approved by the U.
Food and Drug Administration. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Skip to Content. Suicidal Thoughts and Behaviors Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Day 2: Twice daily dosing totaling mg. Day 3: Twice daily dosing totaling mg. Day 4: Twice daily dosing totaling mg. Day 5: Twice daily dosing totaling mg. Based on response and tolerability, may be administered three times daily. What is the most important information I should know about Seroquel?
Seroquel may cause serious side effects, including: 1.
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Medicines like Seroquel can increase the risk of death in elderly people who have memory loss dementia. There is a risk of tardive dyskinesia uncontrollable, repetitive, facial movements associated with all antipsychotics, including Seroquel. Significant weight loss has been reported, although may cause weight gain in some people.
May precipitate a manic episode in people with undiagnosed bipolar disorder.
Mar 01, Seroquel (quetiapine) is an antipsychotic medicine. It works by changing the actions of chemicals in the brain. Seroquel is used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old. Seroquel is also used together with antidepressant medications to treat. Jan 09, I think back in the day, dating was more loosely going on dates with one or many people, but now dating is the past's equivalent of 'going steady.' - Drew, 24 It means you are in a benjamingaleschreck.comg: seroquel. Nov 25, What is the typical starting dose that would be prescribed to someone taking Seroquel? The FDA recommends a starting dosage of 25mg twice a day for the treatment of schizophrenia. The safety of doses above mg per day has not been established. Dosage may differ for the extended-release version of the medication and for the treatment of.
May cause lowering of total body sodium hyponatremia ; elderly people or people taking diuretics or already dehydrated may be more at risk. May cause a discontinuation syndrome if abruptly stopped; symptoms include irritability, low mood, dizziness, electric shock sensations, headache and confusion. High blood sugar levels that may lead to the development of diabetes and elevations in cholesterol or triglyceride levels have been reported.
Hypothyroidism low thyroid levels associated with Seroquel use may also occur. As with similar medications, Seroquel may increase the risk of suicidal thoughts or behavior in young adults; risk is higher in those aged less than The extended-release form of Seroquel should not be given to anyone younger than 18 years.
Tips Immediate-release tablets can be administered either with or without food. Administer extended release tablets in the evening either without food or following a light meal. Swallow extended-release tablets whole, do not crush or chew.
Initially, lower dosages are administered. These are gradually increased as needed so that tolerance develops to side effects such as drowsiness or low blood pressure.
Get up slowly when going from a lying or sitting position to standing. Seroquel may be given once a day or given multiple times a day depending on your doctor's instructions and the type of tablet given for example, immediate vs extended release.
Do not drive or operate machinery or perform hazardous tasks if Seroquel makes you sleepy. Talk to your doctor if you feel that your mood is worsening or you feel agitated or are having suicide-related thoughts. Avoid alcohol while taking Seroquel and keep hydrated.
Avoid over-exercising. Tell your doctor if you experience any abnormal facial movements. Response and Effectiveness Peak levels of Seroquel are reached 1. Sedative effects happen almost immediately; however, it may take up to two to three weeks to see some improvement in other symptoms and up to six weeks for the full effects to be seen.
Interactions Medicines that interact with Seroquel may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Seroquel. Common medications that may interact with Seroquel include: amiodarone clozapine CYP3A4 inducers, such as carbamazepine, oxcarbazepine, phenytoin, rifampin, St John's Wort CYP3A4 inhibitors, such as clarithromycin, cyclosporine, fluconazole, ketoconazole, nefazodone, ritonavir, tamoxifen, verapamil dexamethasone, methylprednisone, and prednisone HIV medications, such as indinavir, nelfinavir, and ritonavir medications used to treat Parkinson's Disease, such as cabergoline and levodopa other antidepressants or antipsychotics methadone sotalol valproate.
Avoid drinking alcohol or taking illegal or recreational drugs while taking Seroquel. References Seroquel quetiapine fumarate [Package Insert]. Drug Status Availability Prescription only Rx.